CONCLUSION: In spite of widespread reported use, there are no studies of IV GSH use for skin lightening or of its safety for chronic use (for any indication)
IV therapy helps brighten the skin by inhibiting the activity of tyrosinase, the enzyme responsible for melanin production
The most effective way to increase the body's glutathione levels is through intravenous infusion, which directly enters the bloodstream and initiates the antioxidant process immediately
WebMD Heart Disease and Homocysteine 33
Last reviewed: June 15, 2026 Last updated: June 15, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations