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Dramatic weight loss seen in clinical trials prompted this new indication
doi:10.1111/bcp.15816 186
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The SNAC absorption enhancer only works under narrow conditions: The dosing protocol: Take Rybelsus first thing in the morning on an empty stomach (at least 6 hours since last food) Swallow tablet whole with no more than 4 ounces (half a cup) of plain water Do not crush, split, or chew the tablet Wait at least 30 minutes before eating, drinking, or taking other oral medications Longer wait times (60 to 90 minutes) may improve absorption but are not required Breaking any of these rules reduces absorption by 50% to 70%
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