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Its pharmacological profile is inferred from in vitro work and from studies of native IGF-1 and the FDA-approved recombinant IGF-1 (mecasermin/Increlex)
These principles are aligned with recommendations outlined in the recent Lancet Commission on diabetes [339]
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This mechanism is supported by the observation that muscle cramps and aches often improve rapidly with electrolyte supplementation
Although GLP-1RAs have inhibitory effect on sodium hydrogen exchanger-3 in tubules, it is unclear that renoprotective effect of GLP-1RAs is attributable to hemodynamic effect [44]
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