At Done Done Fitness, our stance is clear: We are not against GLP-1 medications
It is absolutely possible to overdose on semaglutide, and the results can be very serious
Semaglutide, a GLP-1 receptor agonist, is commonly used for weight management and to help control blood sugar levels in individuals with type 2 diabetes
Again, some level of consideration will have to be made for initial starting BMI, but just like the obese patients, a treat-to-target dose that considers weight + A1c goals should be the aim going forward
However, OCTN1 and OCTN2 both have narrower substrate specificity compared to polyspecific OCTs and OATs, and uptake assays performed with a large panel of drugs suggest that OCTN2 is not a general drug transporter 3,12,17,18