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It was also postulated that cryptorchidism is a part of testicular dysgenesis syndrome along with hypospadias, testis cancer, and reduced semen quality [91]

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27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication