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These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]

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We can effectively incorporate these medications into a personalized weight-loss plan, in conjunction with a reduced-calorie diet and regular physical activity

62.9% of patients achieved more than 20% weight loss compared to 1.3% on lifestyle changes alone