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Since fat-6 and fat-7 share significant sequence homology, both genes are effectively knocked down by fat-6 RNAi

With newer GLP-1based therapies now emerging, the field has an opportunity to test whether different drugs in this class have distinct effects on aging biology and to identify which patients may benefit most. Larger clinical trials are needed to confirm the findings, determine how long treatment effects last, and establish optimal dosing and treatment duration for both people with HIV and the broader population

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The semaglutide component benefits from the extensive SUSTAIN, STEP, and SELECT trial databases

And so will they get some systemic effects