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Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy
It appears to: improve blood flow by improving the utilization of fatty acids for energy, which can help reduce muscle fatigue, increase oxygen supply to the affected limbs, and improve walking capacity reduce symptoms, such as leg pain (claudication), and improve the walking distance before the onset of pain