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Description

Journal of Clinical Investigation, 135 , e184636

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Metformin Metformin is not FDA-approved for weight loss, but it produces modest weight reduction (2-3% of body weight) as a side effect of its primary mechanism, improving insulin sensitivity and reducing hepatic glucose production

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Cooiman MI, Alsters SIM, Duquesnoy M, et al

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Try the step-up protocol (fiber, hydration, Miralax) for 2-4 weeks first

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