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In summary, semaglutide represents a significant advancement in the treatment of diabetes and obesity, but its use must be navigated with an awareness of potential side effects like yeast infections
To examine the requirement of the peptide hormone N-terminus for receptor activation, we fused full length or N-terminally truncated GLP-1 or EX4 peptide via a 15 amino acid linker (five copies of Gly-Ser-Ala [5xGSA]) to the N-terminus of GLP-1R (Figure 1b)
doi: 10.1038/nm.4257 106 KindeB.WuD
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Front Physiol 13:983961
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