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"These drugs have the potential to bring about substantial weight loss, particularly in the first year," says Juan Franco, co-lead researcher from Heinrich Heine University Dsseldorf, Germany
The wider therapeutic scope sustains the GLP-1 diabetes drugs market when core diabetes growth moderates and competitors crowd first-line positions
Annu Rev Physiol
The difference is how many hormone pathways each one engages
Metformin is a widely prescribed, first-line oral antidiabetic agent that acts primarily through activation of AMP-activated protein kinase (AMPK), a key regulator of glucose metabolism, insulin sensitivity, and inflammation 13,14
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