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373 These mechanistic insights are now being translated into rationally designed combination regimens in clinical trials, marking a significant shift toward biology-driven therapeutic strategies (Table 3)

Additionally, it regulates matrix metalloproteinases (MMPs), ensuring balanced degradation of damaged structural proteins alongside newly synthesized matrix assembly

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308,316 To address this evolutionary challenge, ecology- and evolution-informed treatment paradigms have been proposed

Treatment Consistency Following the prescribed treatment schedule and attending routine follow-up appointments helps providers evaluate progress and make individualized recommendations when appropriate