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In permeabilized adipocytes, OCR in response to CI substrate (pyruvate), but not CII (succinate), CIII (duroquinol) or CIV (tetramethyl-p-phenylenediamine (TMPD)/ascorbate), was reduced in Bmal1 -deficient cells (Fig

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However, and interestingly, data also suggested that while GSTP1-1 engages TRAF2 in its dimeric form, only one monomer is involved in binding and therefore the other may still be catalitically competent 30

Edwards, J

Furthermore, by inhibiting the enzyme tyrosinase, which catalyzes the conversion of tyrosine to melanin, L-glutathione prevents the synthesis of melanin