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a single dose methylcobalamin of 1500 mcg in patients with peripheral neuropathy"

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A., Pehar, M., Killoy, K

Why cysteine is the rate-limiting factor: The intracellular concentration of cysteine sits close to the Km value of GCL (0.1 to 0.3 mM), meaning the enzyme is operating near its saturation point under normal conditions

4c, we show that treatment with ENDO3 decreased endolysosomal activity, which recapitulated what was observed in Munc13-4-deficient cells 16 , further validating that the ENDO compounds inhibit Munc13-4-mediated endosomal maturation