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Previous studies have demonstrated that stress induces the maturation and apoptosis of CD4 and CD8 T cells, leading to the depletion of the T cell pool (228)

For GLP-1 users, those outcomes are not theoretical, they map directly onto daily challenges around energy dips, under-eating and nutritional adequacy

That can support appetite reduction, but it may also increase fullness, nausea, bloating, or reflux

As mentioned above, the two main identified proteases for the degradation of GLP-1 in vivo are DPP-4 and NEP-24.11

This may explain how the drug helps curb emotional eating and other behaviors that contribute to weight gain, according to one small study of people with obesity