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This "closed-loop" AI-guided design represents a blueprint for chitosan-DOX optimization, where similar neural network architectures could predict ideal chitosan molecular weight, degree of deacetylation, and ligand density based on breast cancer subtype-specific receptor expression profiles derived from patient biopsy RNA-seq or imaging biomarkers [209]. Predictive modelling of drug release kinetics from chitosan nanoparticles has achieved clinical-grade accuracy through machine learning

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