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Study B, employing a crossover design, demonstrated that twice-daily PT-141 administration resulted in greater mean body weight reduction (1.7 kg) versus placebo (0.9 kg)

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This mechanism is possibly related to the action of IL-10 on neuroblastic cells, increasing the expression of CD138 and leading to the activation of FGF2, which causes neoplastic proliferation and adhesion of malignant cells to the extracellular matrix, prevents mobility, and allows for increased cell invasion and metastasis

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