Patients should be advised to report new or worsening symptoms including jaundice (yellowing of skin or eyes), dark urine, pale stools, persistent right upper quadrant pain, or unexplained fatigue
For example, the upregulation of the Nrf2 pathway by lipoic acid in cultured hepatocytes and in the liver of obese or diabetic rats prevented lipid overload-induced steatosis (35) and cell death (36)
When a craving strikes, do not instantly forbid it, which only heightens its psychological power
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It is essential to keep the medication in its original packaging to protect it from moisture and light