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Regarding the secondary endpoint of the proportion of patients achieving 20% body weight reduction within the study, there was a dose-dependent group size of 50% of the participants receiving the dose of 10 mg tirzepatide and a proportion of 57% in the study arm with 15 mg
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Permanently increased IIS with consecutive down-regulation of nuclear FoxO levels may thus promote the development of cancer [14]
This suggests it could help support a healthier skin microbiome over time
Link Gulak MA, Murphy P
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