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Studies show that direct injection onto lyophilised powder reduces bioactivity by 1218% compared to wall-injection methods, and vigorous shaking causes 2535% degradation even when the solution appears visually clear
This experiment was motivated by the observation that tamoxifen inhibited bovine brain cAMP phosphodisterase
10.4103/1673-5374.355766 113 HuQ.ZuoT.DengL.ChenS.YuW.LiuS.et al (2022a)
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