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2020;12:eaaw4974
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer
Preclinical Research on GHK-Cu and Cellular Regeneration Preclinical research on GHK-Cu explores fibroblasts, collagen, glycosaminoglycans, angiogenesis, inflammation, matrix metalloproteinases, tissue inhibitors, and wound models [4], [5], [10], [12]
The length of each intervention consisted of an 11-week drug titration period as per its monograph, which was followed by 4 weeks of AID use for the primary outcome assessment
Briefly, a closed testing procedure that operated based on an overall significance level of alpha = 0.05 was allocated to the initial test, which was either a test of non-inferiority for SEM 14 mg compared to active comparators (empagliflozin in PIONEER 2 and sitagliptin in PIONEER 3) or a test of superiority for SEM 14 mg compared to placebo (PIONEER 1, 4, and 8)
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