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From an experimental design perspective, the key hypothesis is not that the peptides duplicate each others effects, but rather that they might support different rate-limiting steps in repair, such as cell recruitment to the injury site, fibroblast function, extracellular matrix organization, angiogenesis, and the transition from inflammatory signaling to remodeling

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In eukaryotes, TML is the product of lysosomal or proteasomal degradation of proteins such as calmodulin, myosin, actin, cytochrome c, and histones, which contain N -methylated lysine residues from post-translational modification (Strijbis et al., 2010)

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