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According to 3 multicenter, randomized, double-blind, placebo-controlled obesity trials (BMI 30, or BMI 27 with at least 1 comorbidity of hypertension, dyslipidemia, or type 2 diabetes) conducted to evaluate the effect of CONTRAVE in conjunction with reduced caloric intake and increased physical activity, the average percentage of weight loss in patients at 56 weeks ranged from 3.7% to 8.1% with CONTRAVE, compared to 1.3% to 4.9% with placebo
The most commonly observed side effects in the trial were nausea, diarrhea, and vomiting
GLP1 therapies may exert antiinflammatory effects by reducing proinflammatory cytokines, which could theoretically lessen inflammatory stress on neural circuits involved in mood
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