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The RENAAL trial (N=1,513, mean follow-up 3.4 years) showed losartan reduced the risk of doubling serum creatinine by 25% compared to placebo over the long term, demonstrating net kidney protection despite the early apparent rise

GLP-1 receptor agonists work by increasing the levels of the hormone GLP-1 in the body, which helps to increase the bodys sensitivity to insulin and reduce hunger

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These molecules are more resistant to degradation by DPP-4, which results in a prolonged half-life in comparison with endogenous GLP-1

Patients must also stay hydrated and consult their trusted medical providers for personalized advice when symptoms persist