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doi:10.1016/S0002-9378(98)70645-3

These benefits, along with already widespread use and generally good tolerability profile, have piqued interest in the potential benefit of SGLT2i and GLP1-RA in patients with rheumatologic conditions, who are at higher risk of cardiovascular and renal complications

Lethargy and reduced energy peak 24 hours post-dose, which is why nighttime administration is standard

In more specialized testing , we can look for elevated oxidized glutathione, nitric oxide and urinary 8OHdG (8-hydroxydeoxyguanosine), and decreased reduced glutathione and urinary NAC (N-acetylcysteine) to identify oxidative stress