Autoimmune Progesterone Dermatitis (APD) also known as progestogen hypersensitivity is a rare immune-mediated reaction in which the body mounts an allergic or autoimmune response to endogenous progesterone or synthetic progestins, leading to cyclical skin and systemic symptoms that worsen during the luteal phase of the menstrual cycle
It also reduces infiltration of inflammatory cells and decreases TNF- and IL-6 protein levels in bronchoalveolar lavage fluid (BALF) in a mouse model of pulmonary fibrosis induced by bleomycin
doi: 10.1016/j.jgr.2016.08.004 92 ChenZZhangZLiuJQiHLiJChenJet al
Gene Expression Modulation GHK-Cu has been shown to modify gene expression in damaged tissues, shifting patterns from those associated with aging and inflammation to those seen in younger, healthier tissues
COX-2 selective NSAIDs (i.e., COX-2 inhibitors or coxibs) inhibit COX-2 more strongly than COX-1, resulting in less gastrointestinal side effects, but potential cardiovascular complications, most notably an increase in the risk of heart attack due to increased blood clotting propensity (see below) (Conaghan 2012)