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Additionally, they activate the AMPK pathway in liver cells, which promotes fatty acid oxidation and reduces lipid accumulation (lipogenesis), offering potential benefits for non-alcoholic fatty liver disease (NAFLD) (Zheng et al., 2024)

Discussion Since the finding that the thiazolidinedione rosiglitazone increased cardiovascular events, much weight has been placed on the safety of novel glucose-lowering drugs

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Foundayo (Orforglipron) Foundayo is the newest FDA-approved GLP-1 weight loss medication, approved in April 2026