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Sci Transl Med 2013;5:209ra151.ArticlePubMed 52
Investigated applications In the published preclinical and clinical literature, the effects of NAD+ (and its precursors) are documented in the following areas: Age-related decline of functions , robustly demonstrated in animal models Mitochondrial dysfunctions , emerging clinical data Neurodegenerative diseases (Alzheimers, Parkinsons), Phase 2 trials Chronic fatigue syndrome , observational data, IV NAD+ therapy Addiction treatment , alcohol, opioids (anecdotal, some studies) Metabolic syndrome and insulin resistance , Phase 2 data with NMN Cardiovascular function , endothelial function, blood pressure Skin aging , cosmetic research Post-COVID long-term symptoms , emerging research Sarcopenia , preclinical and Phase 2 data Buying NAD+: what to look for When buying NAD+ , the decisive criterion is not the price but the verifiability of quality
Methods Sixteen participants with type 2 diabetes that was relatively well-controlled by metformin monotherapy were studied on four separate days in a crossover design
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