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Years ago I explored the cost of Marketing Authorisation Holders (those who sell produce and supply B12 in the UK) applying for a new classification

The liver stores B12, and these stores can last a significant time (up to several years for non-deficient individuals), but when they are depleted, it takes consistent input to rebuild and maintain them

Seek urgent medical attention if you experience severe abdominal pain, persistent vomiting, signs of an allergic reaction, chest pain, or dehydration, and inform the clinician of the substance used

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Opened vials: yes, refrigerate at 2-8C