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Patients should start with the 3mg dose for one month (for initiation only, not for glycaemic control), before escalating to 7mg, with a further increase to 14mg if additional glycaemic control is needed

Retatrutide addresses appetite suppression, GLP-1/GIP/glucagon signaling, and body composition while MOTS-c targets mitochondrial efficiency, insulin sensitivity, and exercise-mimicking pathways

In female bodies, excess fat skews hormone levels, increasing insulin and androgen levels and disrupting leptin signaling

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It also allows for Mounjaro to work as effectively as possible