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Without enough vitamin B12, red blood cells may have trouble getting out of the bone marrow because they will not divide normally and are too large to move into the bloodstream

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Within the suppressive TME, immature or dysfunctional DCs typically exhibit reduced major histocompatibility complex (MHC) II and CD86 expression, which limits antigen presentation and impairs effective T-cell priming (138)

But reactions do happen, and recognizing them early prevents unnecessary skin damage