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Am J Psychiatry
Anticancer Drug Oxaliplatin Induces Acute Cooling-Aggravated Neuropathy via Sodium Channel Subtype NaV1.6-resurgent and Persistent Current
less water means a tighter stock but less margin for measurement error
245 JAK2/STAT3 signaling also plays a pivotal role in CD8 T-cell exhaustion
Its mechanism involves simultaneous modulation of multiple neurotrophic pathways: BDNF-like Activity: Components mimic brain-derived neurotrophic factor signaling, promoting neuronal survival and plasticity GDNF-like Activity: Glial cell line-derived neurotrophic factor-like effects support dopaminergic neuron survival CNTF-like Activity: Ciliary neurotrophic factor-like components support oligodendrocyte and motor neuron function Anti-apoptotic Effects: Reduces caspase-mediated neuronal apoptosis in ischemic and neurodegenerative models Amyloid Modulation: Some evidence suggests effects on amyloid precursor protein processing relevant to Alzheimer's disease research Fundamental Contrast: Dihexa represents a reductionist approach one molecule, one target (HGF/c-Met), exceptional potency
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