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S -transferase from antarctic bivalve Laternula elliptica reveals novel active site architecture"

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While subpockets B and C are rather large, subpocket A is narrow and restricted in depth by FAD at the bottom of the pocket, limiting the choice of modifications of the inhibitor in subpocket A

Factor in the rapid clearance mechanism, whereby nasally-applied drugs are cleared with a half-life of approximately 21 minutes, and its clear why only certain peptides can be used nasally

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