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As a thrombopoietin receptor agonist, Romiplostim activates cellular transcription pathways through the c-Mpl receptor (thrombopoietin receptor) to increase platelet production
(2024) 103:e38189
Peptides were separated by chromatography with the following parameters: Acclaim PepMap100 C18 pre-column (2 cm, 75 m i.d., 3 m, 100 ), Pepmap-RSLC Proxeon C18 column (75 cm, 75 m i.d., 2 m, 100 ), 300 nl/min flow rate, using a gradient rising from 95% solvent A (water, 0.1% formic acid) to 40% B (80% acetonitrile, 0.1% formic acid) in 120 min, followed by a column regeneration of 20 min, for a total run of 140 min
Nausea usually resolves by day 4-5 as your body adapts