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High-fat meals delay gastric emptying independently of cagrilintide, so dosing before a high-fat dinner can compound the effect and increase nausea risk

In a phase II study of the long-acting GLP-1RA efpeglenatide (4 mg once weekly, 6 mg once weekly, 6 mg once every 2 weeks, and 8 mg once every 2 weeks), patients with obesity and without diabetes had statistically significant reductions in body weight compared with placebo after 20 weeks of treatment (differences in least squares means were 6.3 to 7.2 kg

Preclinical research has investigated BPC-157 for a wide range of applications, including gastrointestinal healing (ulcers, NSAID-induced gut damage, intestinal permeability), tendon and ligament repair, muscle recovery from crush injuries, peripheral nerve regeneration, and neuroprotection

These findings suggest that Puerariae lobatae radix prevents follicular depigmentation by stimulating melanin synthesis

JAMA 2024;332:12:952-953