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Additionally, gastrointestinal side effects, such as nausea, vomiting, and diarrhea, are commonly associated with GLP-1 receptor agonists, especially during the initial phase of treatment
In addition, local necrosis was evident from the centralized globular hyperintense signal in both coronal and transverse images
One study showed that: Oleic acid helped stimulate GLP-1 secretion whereas saturated fatty acids didnt. But why
Factors that may limit response include structural damage beyond soft tissue (bone spurs, severe stenosis), very long chronicity where adaptive changes have become entrenched, underlying conditions requiring different treatment (infection, tumor, autoimmune disease), and individual variation in peptide metabolism or receptor sensitivity