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Neuroprotective effects via PI3K/Akt/GSK-3 and IGF-1PI3K-AktmTOR signaling further contribute to reduced muscle degradation and improved protein synthesis
For the cerebrovascular uptake study ( n = 22), male and female homozygous APOE2-, APOE3-, and APOE4-TR mice were euthanized at 26-weeks (Supplementary Table S2)
These include acute pancreatitis, acute kidney injury, severe gastrointestinal bowel obstruction, and potential medullary thyroid tumors
Int J Clin Pharmacol Ther Toxicol
Julie Colvin
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