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The induction of ICD in tumor cells during PDT treatment is primarily attributed to the generation of intracellular ROS under NIR irradiation, which occurs after photosensitizer aggregation in the ER, causing disruptions in ER homeostasis, elevating calcium levels in the ER, and losing SERCA2 function
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Calderon Toledo C, Rogers TJ, Svensson M, Tati R, Fischer H, Svanborg C, Karpman D (2008) Shiga toxin-mediated disease in MyD88-deficient mice infected with Escherichia coli O157:H7
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