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118 In ER/HER2 breast cancer, hyperactivated AKT1 binds to the kinase domain of TBK1, disrupting the STING-TBK1-IRF3 complex, thereby impairing downstream interferon signaling and blocking innate immune responses triggered by DNA damage

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Dose increases happen every 4 weeks

Chronic oxidative stress induces premature senescence of muscle stem cells (MuSCs), diminishes their self-renewal capacity, and downregulates the SIRT1/Nrf2 axis, weakening antioxidant and DNA repair systems ( 2 O 2 accumulation and oxidative damage

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