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Acknowledgements The authors acknowledge support from the National Institutes of Health (grants R01-CA131524, P01 CA025874 and 5T32CA177555-02), the Gerson and Barbara Bass Bakar Distinguished Professorship in Cancer Research and the Terry Patters Memorial Foundation

When elevated, there was increased fat accumulation, reduced metabolic efficiency, and mitochondrial dysfunction

SJ: Supervision, Writing review & editing, Funding acquisition, Resources, Project administration, Validation, Methodology, Conceptualization, Formal analysis

Further studies are required to understand its effectiveness

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