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Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases
Palmitoylation of caveolin-1 is regulated by the same DHHC acyltransferases that modify steroid hormone receptors
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Patients should discuss eligibility for these treatments with their GP or a specialist obesity service, as access criteria, commissioning arrangements, and availability vary across NHS regions
Timeline of effects : Weeks 14 : Many patients notice reduced appetite and early changes in food-related thoughts, though gastrointestinal adjustment may be prominent Months 23 : Progressive weight loss typically becomes evident, with continued reduction in food preoccupation Months 412 : Weight loss generally continues, with Wegovy clinical trials showing approximately 10-15% weight reduction by around 68 weeks [12] [5] Weight loss outcomes vary considerably between individuals
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