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The functional consequence in animal models is synergistic rather than additive GH output: GHRH-R priming increases the pool of releasable GH vesicles, and GHS-R1a co-stimulation then drives a larger amplitude pulse than either receptor produces alone
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Highlights Type 2 diabetes mellitus (T2DM) is currently a global epidemic, affecting 537 million individuals worldwide
2021 Dec 3;13(12):4359
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