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For most patients, GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) require long-term use to maintain their benefits
Accumulation of metabolites (such as trimethylamine) may increase the risk of side effects
Researchers believe diarrhea can occur because Ozempic changes how the intestines absorb certain nutrients, such as sugar and fats
You may also get side effects like nausea, vomiting, diarrhoea and headaches
The relative ranking of dose combinations remained consistent, with the highest probabilities observed for semaglutide 2.4 mg vs tirzepatide 10 mg and semaglutide 7.2 mg vs tirzepatide 15 mg
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