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Furthermore, considering the complexity of the pathogenesis of NAFL/NASH, the synergistic use of drugs with different mechanisms and personalized treatment plan may better benefit patients, especially for the combination of lifestyle changes and pharmacological interventions
A patient with favorable GLP1R variants may achieve strong semaglutide response at lower doses, while someone with different genetic markers might benefit from combination therapy or higher dosing strategies
three upregulated genes related to Grx , 5-OPase , and APX exhibited a higher expression in the EI501 vs
That means for every kilogram of weight lost on semaglutide, nearly half was muscle rather than fat
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