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The company has three drug candidates in clinical development for ophthalmic, cardiac, and dermal indications , with RGN-259 receiving orphan drug designation for neurotrophic keratopathy

The significance of this paper is not only to compare the three routes of administration but also to evaluate them and determine which route is the best to administrate the drug

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Similarly, APLP2 could bind to AP-2, mediate effective internalization and direct to lysosomal degradation after clathrin-mediated endocytosis [82]