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Rhythms 33 , 363375 (2018)

Similarly, dysregulated inflammation drives the development and progression of autoimmune disorders including rheumatoid arthritis, psoriasis, systemic lupus erythematosus, asthma, and inflammatory bowel diseases (ulcerative colitis and Crohns disease) (Berg et al., 2010)

Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert PM, Chen J, et al

The peptide exhibits consistent efficacy in models of acute and chronic injury regardless of administration route (intraperitoneal, oral, or local application), a unique characteristic distinguishing it from other growth factors that typically require localized delivery with carrier systems

Brown Norway rats that did not undergo any treatment (PQ or eye drops) were also included as a healthy untreated control group