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Treatment with the selective GLS1 inhibitor BPTES reduced glycolysis and ameliorated lupus-like disease and EAE in MRL/lpr mice ( + CD4 - CD8 - cells), the urinary albumin/creatinine ratio, glomerular nephropathy score, and T-cell infiltration with IL-17A in the kidneys, relieving the EAE disease activity ( + T cells by inhibiting GLS1, glycolysis, and CD4 + T-cell differentiation in vitro by reducing the level of HIF1 protein, a key metabolic sensor in Th17 cells ( Table 1 )
A small retrospective study of 12 patients with chronic knee pain found 91.6% reported significant improvement after intra-articular BPC-157 injection, but this lacks a control group and has not been replicated
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Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration
The effect of inositol supplementation on blood pressure: A systematic review and meta-analysis of randomized-controlled trials
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