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Researchers have found high glucose can activate inflammasome, cause inflammatory cytokines release, and induce pyroptosis in proximal tubule epithelial cell line (124)

Many systematic reviews with network meta-analysis summarized the risk of noval hypoglycemic drugs on diabetic complications, including cardiovascular events, nonfatal stroke, renal composite outcomes and fatty liver (45)

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doi: 10.3390/ijms19123851 42 ZhuJVan den EyndeB

GLP-1oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone new Zealand obese (NZO) mice