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Conversely, mice overexpressing ornithine transcarbamylase (a LONP1 substrate) recapitulate osteoporosis, muscle wasting, and frailty, which further confirms the critical role of LONP1-dependent PQC in preserving muscle mass and strength [133, 134]
Because these polymorphisms have a high frequency, [60] they may have a substantial effect at the population level
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Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice
PLoS One 10 , e0127527 (2015)
