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At 65.3% of the 12 mg arm reaching BMI below 30 by week 80, the metabolic normalization rate is the highest reported in any obesity pharmacotherapy trial
The nanoparticles displayed exceptional pH sensitivity, releasing nearly 100% of DOX at pH 5.5 but only approximately 13% at physiological pH 7.4, following a Fickian diffusion mechanism that ensures sustained intratumoral drug availability
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